India is aggressively scaling nano urea, but experts urge caution regarding its long-term public health and environmental safety. Because nanoparticles penetrate biological barriers, they may cause oxidative stress and chronic toxicity. Currently, India lacks sufficient post-market surveillance and long-term data. Experts recommend adopting a precautionary, evidence-based approach—including independent safety validation and robust monitoring—before further widespread adoption, ensuring potential benefits do not overshadow critical, unrecognized risks.